The EMBO Meeting

The EMBO Meeting 2012

 

 

 

 

Monday, 18 Nov 2013

ADP-ribosylation in signalling events

Saturday, 22 September, 10:00-17:30, Rhodes 7

Participants need to register for The EMBO Meeting 2012 to attend this special interest symposium.

Understanding protein modifications can provide powerful tools to study basic biology, and open new avenues for disease treatment. Recent years have seen a tremendous rise in both interest in, and understanding of, the players, mechanisms, and consequences of ADP-ribosylation. A fair understanding of this process is deemed important not the least for the development of safe therapeutics for treatment of cancer. Here, European researchers will present their recent data on the writers, readers, and erasers of ADP-ribosylation.

For further information, please contact the organizer: This e-mail address is being protected from spambots. You need JavaScript enabled to view it


Programme

10:00

Welcome address

10:00-10:30

Raffaella Santoro, Zurich
Non-coding RNA link PARP1 to heterochromatin

10:30-11:00

Françoise Dantzer, Strasbourg
Novel functions of PARPs in heterochromatin dynamics: molecular and cellular aspects

11:00-11:20

Antonio Macchiarulo, Perugia
From Target Specificity to Targeted Polypharmacology of PARP Inhibitors

11:20-11:40

Herwig Schüler, Stockholm
A chemical probe for ARTD3/PARP3

11:40-12:00

Friedrich Koch-Nolte, Hamburg
Blocking mammalian and toxin ARTCs with Nanobodies

12:00-13:00

Lunch break

13:00-13:30

Mariella di Girolamo, Santa Maria Imbaro
ADP-ribosylated proteins as old and new drug targets for anticancer therapy

13:30-14:00

Bernhard Lüscher, Aachen
Regulation of NF-kB signaling by ARTD10-dependent mono-ADP-ribosylation

14:00-14:30

Stefan Krauss, Oslo - CANCELLED
Selective tankyrase inhibitors as modulators of Wnt/b-catenin signaling

14:30-14:50

Lari Lehtiö, Oulu
Selective Inhibition of Tankyrases

14:50-15:10

Coffee break

15:10-15:40

Ivan Ahel, Manchester
Structure and catalytic mechanism of PARG

15:40-16:00

Martin Högbom, Stockholm
Structure and Mechanism of mono-ADP-ribosylhydrolase DraG

16:00-16:30

Gyula Timinszky, München
The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks

16:30-17:00

Mathias Ziegler, Bergen
ADP-ribose and NAD metabolism in mitochondria

17:00

Conclusion

17:30

The EMBO Meeting Welcome Address

The EMBO Meeting
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